Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 496462
Title The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: where time and place matter
Author(s) Koets, A.P.; Eda, Shigetoshi; Sreevatsan, Srinand
Source Veterinary Research 46 (2015). - ISSN 0928-4249 - 17 p.
Department(s) CVI Bacteriology and Epidemiology
Publication type Refereed Article in a scientific journal
Publication year 2015
Abstract Johne’s disease or paratuberculosis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), occurs in domestic
and wild animals worldwide, causing a significant economic loss to livestock industries. After a prolonged incubation
time, infected cattle shed MAP bacilli into feces and spread the disease to an uninfected animal population. It is largely
unknown how (or whether) the interplay between the pathogen and the host immunity determines timing of shedding
after the long incubation time. Such information would provide an understanding of pathogenesis in individual animals
and the epidemiology of MAP infection in animal populations. In this review, we summarize current knowledge of
bovine Johne’s disease pathology, pathogenesis, immunology and genetics. We discuss knowledge gaps that direly
need to be addressed to provide a science-based approach to diagnostics and (immuno)prophylaxis. These knowledge
gaps are related to anatomical/clinical manifestation of MAP invasion, interaction of bacteria with phagocytes, granuloma
formation, shedding, establishment and kinetics of adaptive immune responses in the pathogenesis of the disease. These
topics are discussed at the molecular, cellular and tissue levels with special attention to the within host dynamics
including the temporal and the spatial context relevant for the various host-pathogen interactions.
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