| Record number | 496792 |
|---|---|
| Title | Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia |
| Author(s) | Dijk, S.C. van; Enneman, A.W.; Swart, K.M.A.; Wijngaarden, J.P. van; Ham, A.C.; Jonge, R.; Blom, H.J.; Feskens, E.J.M.; Geleijnse, J.M.; Schoor, N.M. van; Dhonukshe-Rutten, R.A.M.; Jongh, R.T. de; Lips, P.; Groot, C.P.G.M. de; Uitterlinden, A.G.; Meiracker, A.H. van den; Mattace-Raso, F.U.S.; Velde, N. van der; Smulders, Y. |
| Source | Vascular Medicine 21 (2016)2. - ISSN 1358-863X - p. 91 - 98. |
| DOI | http://dx.doi.org/10.1177/1358863X15622281 |
| Department(s) |
Human Nutrition (HNE) Chair Nutrition and Health over the Lifecourse VLAG Chair Nutrition and Disease CS OnderwijsinstituutOnderwijsinstituut |
| Publication type | Refereed Article in a scientific journal |
| Publication year | 2016 |
| Abstract | B-vitamin trials failed to demonstrate beneficial effects on cardiovascular outcomes, but hyperhomocysteinemia still stands out as an independent cardiovascular risk factor, particularly in elderly individuals. B-vitamins may influence early vascular dysfunction, such as endothelial dysfunction, or may have adverse effects, for example on inflammation. We investigated the effect of B-vitamins on endothelial function and inflammation within an interventional study. This study was conducted within the framework of the B-PROOF trial, which included 2919 hyperhomocysteinemic elderly individuals, who received daily vitamin B12 (500 μg) and folic acid (400 μg) or placebo for 2 years. Using an electrochemiluminescence platform, we measured intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule 1 (VCAM-1), serum amyloid A (SAA), vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) at baseline and follow-up in a subsample of 522 participants (271 intervention group; 251 placebo). Treatment effects were analyzed with ANCOVA. The participants had a mean age of 72 years, and 55% of them were male. At the 2-year follow-up, B-vitamins did not change the ICAM-1 (+36% change in the intervention group versus +32% change in the placebo group; p = 0.72), VCAM-1 (+27% vs +25%; p = 0.39), VEGF (–1% vs +4%; p = 0.40), SAA (+34% vs +38%; p = 0.85) or CRP levels (+26% vs +36%; p = 0.70) as compared to placebo. In conclusion, in elderly patients with hyperhomocysteinemia, vitamin B12 and folic acid are unlikely to influence either endothelial function or low-grade systemic inflammation. ClinicalTrials.gov Identifier: NCT00696514 |
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