Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 496939
Title Feather segmentation to discriminate between different enrofloxacin treatments in order to monitor off-label use in the poultry sector
Author(s) Jansen, L.J.M.; Bolck, Y.J.C.; Berendsen, B.J.A.
Source Analytical and Bioanalytical Chemistry 408 (2016). - ISSN 1618-2642 - p. 495 - 502.
DOI http://dx.doi.org/10.1007/s00216-015-9118-z
Department(s) RIKILT - Business unit Dierbehandelingsmiddelen
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2016
Abstract Antibiotics are commonly used in the poultry industry
to treat bacterial infections. In the combat against bacterial
resistance, policies require, besides a reduction of antibiotic
usage in humans and animals, an up-to-date farmer
registration mentioning all treatments. For enforcement of
such policies, tests are needed to antedate administration and
to determine the type of treatment so as to prevent off-label
use and the supervacaneous use of last-resort antibiotics like
cephalosporins and fluoroquinolones. After poultry treatment,
high amounts of enrofloxacin and its metabolite ciprofloxacin
are deposited in chicken feathers. A method is presented to
discriminate different treatments based on differentiating extractable
and non-extractable enrofloxacin and ciprofloxacin
in chicken feathers.With this approach, we show it is possible
to distinguish between a registered therapeutic oral treatment,
an off-label spray treatment and an illegal prolonged subtherapeutic
treatment with enrofloxacin. This approach is a
new and strong tool in the enforcement of new policies in
the fight against off-label and supervacaneous antibiotic use.
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