Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 496940
Title Misspecification in mixed-model-based association analysis
Author(s) Kruijer, Willem
Source Genetics 202 (2016)1. - ISSN 0016-6731 - p. 363 - 366.
DOI https://doi.org/10.1534/genetics.115.177212
Department(s) Biometris (WU MAT)
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Epistasis - Missing heritability - Misspecification - Nonadditive genetic variance
Abstract

Additive genetic variance in natural populations is commonly estimated using mixed models, in which the covariance of the genetic effects is modeled by a genetic similarity matrix derived from a dense set of markers. An important but usually implicit assumption is that the presence of any nonadditive genetic effect increases only the residual variance and does not affect estimates of additive genetic variance. Here we show that this is true only for panels of unrelated individuals. In the case that there is genetic relatedness, the combination of population structure and epistatic interactions can lead to inflated estimates of additive genetic variance.

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