|Title||Versatile Scope of a Masked Aldehyde Nitrone in 1,3-Dipolar Cycloadditions|
|Author(s)||Hoogenboom, Jorin; Zuilhof, Han; Wennekes, Tom|
|Source||Organic Letters 17 (2015)22. - ISSN 1523-7060 - p. 5550 - 5553.|
Laboratory for Organic Chemistry
|Publication type||Refereed Article in a scientific journal|
A new masked aldehyde-containing nitrone 1 that is easily available through a facile one-step procedure has been developed. It undergoes a [3 + 2]-thermal cycloaddition with a wide range of dipolarophiles, affording isoxazolidine cycloadducts that are suitable for versatile postcycloaddition modifications. The acetal cycloadducts are acid-stable, but allow for acetal hydrolysis under mildly basic conditions. The isoxazolidine ring can be opened via an efficient one-pot procedure to give amine-protected γ-alcohols that can be further converted to furanose derivatives.