|Title||The role of auxin signaling in early embryo pattern formation|
|Author(s)||Smit, Margot E.; Weijers, Dolf|
|Source||Current Opinion in Plant Biology 28 (2015). - ISSN 1369-5266 - p. 99 - 105.|
|Publication type||Refereed Article in a scientific journal|
Pattern formation of the early Arabidopsis embryo generates precursors to all major cell types, and is profoundly controlled by the signaling molecule auxin. Here we discuss recent milestones in our understanding of auxin-dependent embryo patterning. Auxin biosynthesis, transport and response mechanisms interact to generate local auxin accumulation in the early embryo. New auxin-dependent reporters help identifying these sites, while atomic structures of transcriptional response mediators help explain the diverse outputs of auxin signaling. Key auxin outputs are control of cell identity and cell division orientation, and progress has been made towards understanding the cellular basis of each. Importantly, a number of studies have combined computational modeling and experiments to analyze the developmental role, genetic circuitry and molecular mechanisms of auxin-dependent cell division control.