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Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 497509
Title Healthy eating and lower mortality risk in a large cohort of cardiac patients who received state-of-the-art drug treatment
Author(s) Sijtsma, F.P.C.; Soedamah-Muthu, S.S.; Goede, J. de; Oude Griep, L.M.; Geleijnse, J.M.; Kromhout, D.
Source American Journal of Clinical Nutrition 102 (2015)6. - ISSN 0002-9165 - p. 1527 - 1533.
Department(s) Chair Nutrition and Disease
Human Nutrition (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2015
Abstract Background: Little is known about dietary scores and mortality
risk in cardiac patients who are well treated with drugs with attendant
relatively low risk of cardiovascular diseases (CVDs).
Objective: We assessed whether healthy eating lowers the risk of
CVD and all-cause mortality in cardiac patients.
Design: We included 4307 patients from the Alpha Omega Trial aged
60–80 y with a clinically diagnosed myocardial infarction and monitored
mortality for 10 y. Diet was assessed at baseline (2002–2006)
with a validated 203-item food-frequency questionnaire. We created 2
dietary scores on the basis of nonoverlapping sets of foods: the Dutch
Healthy Nutrient and Food Score (DHNaFS) and the Dutch Undesirable
Nutrient and Food Score (DUNaFS). The associations of both
dietary scores with CVD and all-cause mortality were assessed by
using multivariable-adjusted Cox regression models.
Results: The median time after myocardial infarction at baseline was
3.7 y (IQR: 1.7–6.3 y). During a median of 6.5 y of follow-up (IQR: 5.3–
7.6 y), 801 patients died; 342 of those died of CVD. One patient was lost
to follow-up. A substantially higher average amount of DHNaFS foods
(w1750 g/d) than DUNaFS foods (w650 g/d) was consumed. Almost
all patients received drug treatment: 86% used statins, 90% used antihypertensive
medication, and 98% used antithrombotic medication. Patients
in the fifth quintile of the DHNaFS had a 30% (HR: 0.70; 95% CI: 0.55,
0.91) lower CVD risk and a 32% (HR: 0.68; 95% CI: 0.47, 0.99) lower
all-cause mortality risk than did patients in the first quintile. The
DUNaFS was unrelated to both CVD and all-cause mortality.
Conclusion: Beyond state-of-the-art drug treatment, healthy eating
was associated with a lower risk of CVD and all-cause mortality in
cardiac patients. This trial was registered at as
NCT00127452. Am J Clin Nutr doi: 10.3945/ajcn.115.112276.
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