Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 497831
Title Dose-response relationship between antimicrobial drugs and livestock-associated MRSA in pig farming
Author(s) Dorado-García, Alejandro; Dohmen, Wietske; Bos, M.E.H.; Verstappen, K.M.; Houben, Manon; Wagenaar, J.A.; Heederik, D.J.J.
Source Emerging Infectious Diseases 21 (2015)6. - ISSN 1080-6040 - p. 950 - 959.
DOI http://dx.doi.org/10.3201/eid2106.140706
Department(s) CVI Infection Biology
Publication type Refereed Article in a scientific journal
Publication year 2015
Abstract

The farming community can be a vehicle for introduction of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in hospitals. During 2011–2013, an 18-month longitudinal study aimed at reducing the prevalence of LA-MRSA was conducted on 36 pig farms in the Netherlands. Evaluations every 6 months showed a slight decrease in MRSA prevalence in animals and a stable prevalence in farmers and family members. Antimicrobial use, expressed as defined daily dosages per animal per year, decreased 44% during the study period and was associated with declining MRSA prevalence in pigs. MRSA carriage in animals was substantially higher at farms using cephalosporins. Antimicrobial use remained strongly associated with LA-MRSA in humans regardless of the level of animal contact. A risk factor analysis outlined potential future interventions for LA-MRSA control. These results should encourage animal and public health authorities to maintain their efforts in reducing antimicrobial use in livestock and ask for future controlled intervention studies.

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