Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 498100
Title Synbiotics-supplemented amino acid-based formula supports adequate growth in cow's milk allergic infants
Author(s) Burks, A.W.; Harthoorn, L.F.; Ampting, M.T.J. Van; Oude Nijhuis, M.M.; Langford, J.E.; Wopereis, Harm; Goldberg, S.B.; Ong, P.Y.; Essink, B.J.; Scott, R.B.; Harvey, B.M.
Source Pediatric Allergy and Immunology 26 (2015)4. - ISSN 0905-6157 - p. 316 - 322.
DOI http://dx.doi.org/10.1111/pai.12390
Department(s) Microbiological Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) Amino acid-based formula - Cow's milk allergy - Growth - Infant - Prebiotics - Probiotics - Randomized double-blind controlled trial - Safety
Abstract

Background: Children with cow's milk allergy (CMA) are at risk for inadequate nutritional intake and growth. Dietary management of CMA, therefore, requires diets that are not only hypoallergenic but also support adequate growth in this population. This study assessed growth of CMA infants when using a new amino acid-based formula (AAF) with prebiotics and probiotics (synbiotics) and evaluated its safety in the intended population. Methods: In a prospective, randomized, double-blind controlled study, full-term infants with diagnosed CMA received either an AAF (control; n = 56) or AAF with synbiotics (oligofructose, long-chain inulin, acidic oligosaccharides, Bifidobacterium breve M-16V) (test; n = 54) for 16 wk. Primary outcome was growth, measured as weight, length and head circumference. Secondary outcomes included allergic symptoms and stool characteristics. Results: Average age (±SD) of infants at inclusion was 4.5 ± 2.4 months. Both formulas equally supported growth according to WHO 2006 growth charts and resulted in similar increases of weight, length and head circumference. At week 16, differences (90% CI) in Z-scores (test-control) were as follows: weight 0.147 (-0.10; 0.39, p = 0.32), length -0.299 (-0.69; 0.09, p = 0.21) and head circumference 0.152 (-0.15; 0.45, p = 0.40). Weight-for-age and length-for-age Z-scores were not significantly different between the test and control groups. Both formulas were well tolerated and reduced allergic symptoms; the number of adverse events was not different between the groups. Conclusions: This is the first study that shows that an AAF with a specific synbiotic blend, suitable for CMA infants, supports normal growth and growth similar to the AAF without synbiotics. This clinical trial is registered as NCT00664768.

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