Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 498113
Title Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring
Author(s) Ewijk, Petronella A. Van; Paglialunga, Sabina; Kooi, M.E.; Nunes, Patricia M.; Gemmink, Anne; Slenter, Jos; Kornips, Esther; Jörgensen, Johanna A.; Hoeks, Joris; Wildberger, Joachim E.; Hesselink, Matthijs K.C.; Glatz, Jan F.C.; Heerschap, Arend; Kersten, Sander; Schrauwen, Patrick; Schrauwen-Hinderling, Vera B.
Source Obesity 23 (2015)11. - ISSN 1930-7381 - p. 2242 - 2250.
DOI https://doi.org/10.1002/oby.21235
Department(s) Chair Nutrition Metabolism and Genomics
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2015
Abstract

Objective Parental high-fat feeding was proposed to negatively impact metabolic health in offspring. Here, the ectopic fat storage in heart and liver in offspring was investigated, and the effects on mitochondrial function, de novo lipogenesis, and postprandial lipid metabolism were explored in detail. Methods Male and female mice received either a high-fat (HF) or standard chow (LF) diet during mating, gestation and lactation. All offspring animals received the HF diet. Results Abdominal visceral adipose tissue tended to be higher in HF/HF mice. Cardiac lipid content was also higher in the HF/HF mice (LF/HF vs. HF/HF: 1.03% ± 0.08% vs. 1.33% ± 0.07% of water signal, P = 0.01). In contrast, hepatic lipid content tended to be lower in HF/HF mice compared to LF/HF mice. A severely disturbed postprandial lipid clearance was revealed in HF/HF mice by the results from the triglyceride (TG) tolerance tests (LF/HF vs. HF/HF: 6,753 ± 2,213 vs. 14,367 ± 1,978 mmol l-1 min-1, P = 0.01) and 13C-fatty acid retention test (LF/HF vs. HF/HF: 2.73% ± 0.85% vs. 0.89% ± 0.26% retention from bolus, P = 0.04), which may underlie the lower hepatic lipid content. Conclusions Here it is shown that HF diet negatively impacts postprandial TG clearance in offspring and results in an overall metabolic unfavorable phenotype and ectopic lipid deposition in the heart and in visceral storage sites.

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