Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 498467
Title Crimean-congo hemorrhagic fever virus subunit vaccines induce high levels of neutralizing antibodies but no protection in STAT1 knockout mice
Author(s) Kortekaas, Jeroen; Vloet, Rianka P.M.; Mcauley, Alexander J.; Shen, Xiaoli; Bosch, Berend Jan; Vries, Laura De; Moormann, Rob J.M.; Bente, Dennis A.
Source Vector-Borne and Zoonotic Diseases 15 (2015)12. - ISSN 1530-3667 - p. 759 - 764.
DOI http://dx.doi.org/10.1089/vbz.2015.1855
Department(s) CVI Virology
Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) Bunyavirus - Crimean-Congo hemorrhagic fever virus - Gc - Gn - Nairovirus - Neutralizing antibodies - STAT1 - STAT129 - Vaccine
Abstract

Crimean-Congo hemorrhagic fever virus is a tick-borne bunyavirus of the Nairovirus genus that causes hemorrhagic fever in humans with high case fatality. Here, we report the development of subunit vaccines and their efficacy in signal transducer and activator of transcription 1 (STAT1) knockout mice. Ectodomains of the structural glycoproteins Gn and Gc were produced using a Drosophila insect cell-based expression system. A single vaccination of STAT129 mice with adjuvanted Gn or Gc ectodomains induced neutralizing antibody responses, which were boosted by a second vaccination. Despite these antibody responses, mice were not protected from a CCHFV challenge infection. These results suggest that neutralizing antibodies against CCHFV do not correlate with protection of STAT1 knockout mice.

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