Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 498476
Title Artificial selection on introduced Asian haplotypes shaped the genetic architecture in european commercial pigs
Author(s) Bosse, Mirte; Soares Lopes, Marcos; Madsen, Ole; Megens, Hendrik Jan; Crooijmans, Richard P.M.A.; Frantz, Laurent A.F.; Harlizius, Barbara; Bastiaansen, John W.M.; Groenen, Martien A.M.
Source Proceedings of the Royal Society. B: Biological Sciences 282 (2015)1821. - ISSN 0962-8452 - 9 p.
DOI http://dx.doi.org/10.1098/rspb.2015.2019
Department(s) Animal Breeding and Genetics
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) Adaptive introgression - Commercial breeding - Domestication - Hybridization - Selection - Sus scrofa
Abstract

Early pig farmers in Europe importedAsian pigs to cross with their local breeds in order to improve traits of commercial interest. Current genomics techniques enabled genome-wide identification of these Asian introgressed haplotypes in modern European pig breeds.We propose that the Asian variants are still present because they affect phenotypes thatwere important for ancient traditional, as well as recent, commercial pig breeding. Genome-wide introgression levels were only weakly correlated with gene content and recombination frequency. However, regions with an excess or absence of Asian haplotypes (AS) contained genes that were previously identified as phenotypically important such as FASN, ME1, and KIT. Therefore, the Asian alleles are thought to have an effect on phenotypes thatwere historically under selection.We aimed to estimate the effect of AS in introgressed regions in Large White pigs on the traits of backfat (BF) and litter size. The majority of regions we tested that retained Asian deoxyribonucleic acid (DNA) showed significantly increased BF from the Asian alleles. Our results suggest that the introgression in Large White pigs has been strongly determined by the selective pressure acting upon the introgressed AS. We therefore conclude that human-driven hybridization and selection contributed to the genomic architecture of these commercial pigs.

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