|Title||Physical and mechanical properties of thermosensitive xanthan/collagen-inspired protein composite hydrogels|
|Author(s)||Pham, Thao T.H.; Snijkers, Frank; Storm, Ingeborg M.; Wolf, Frits A. De; Cohen Stuart, Martien A.; Gucht, Jasper Van Der|
|Source||International Journal of Polymeric Materials and Polymeric Biomaterials 65 (2016)3. - ISSN 0091-4037 - p. 125 - 133.|
Physical Chemistry and Soft Matter
|Publication type||Refereed Article in a scientific journal|
|Keyword(s)||collagen-inspired protein - composite hydrogels - electrostatic interaction - strain-softening - thermosensitivity - Xanthan|
Functionalization of xanthan hydrogels is of interest for biomaterial applications. The authors report characterization of electrostatic complexation of xanthan with a recombinant collagen-inspired triblock protein polymer. This polymer has one charged polylysine end-block that can bind to xanthan by electrostatic interactions, and another end-block that can self-assemble into thermosensitive collagen-like triple helices; the end-blocks are connected by a neutral, hydrophilic, mostly inert random coil. The protein modifies the xanthan/protein composite hydrogels in three ways: (a) a significant increase in storage modulus, (b) thermosensitivity, and (c) a two-step strain softening in nonlinear rheology.