Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 498490
Title Glyceollins and dehydroglyceollins isolated from soybean act as SERMs and ER subtype-selective phytoestrogens
Author(s) De Schans, Milou G.M. Van; Vincken, Jean Paul; Waard, Pieter De; Hamers, Astrid R.M.; Bovee, Toine F.H.; Gruppen, Harry
Source Journal of Steroid Biochemistry and Molecular Biology 156 (2016). - ISSN 0960-0760 - p. 53 - 63.
DOI http://dx.doi.org/10.1016/j.jsbmb.2015.11.020
Department(s) Food Chemistry Group
RIKILT - Business unit Dierbehandelingsmiddelen
VLAG
BioNanoTechnology
ATV NMR Centrum
RIKILT - BU Toxicology Bioassays & Novel Foods
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) 6a,11a-Pterocarpene - 6a-Hydroxy-pterocarpan - hER yeast bioassay - hERα-CALUX - Molar extinction coefficient - Prenylation
Abstract

Seven prenylated 6a-hydroxy-pterocapans and five prenylated 6a,11a-pterocarpenes with different kinds of prenylation were purified from an ethanolic extract of fungus-treated soybean sprouts. The activity of these compounds toward both human estrogen receptors (hERα and hERβ) was determined in a yeast bioassay and the activity toward hERα was additionally tested in an U2-OS based hERα CALUX bioassay. In the yeast bioassay, compounds with chain prenylation showed in general an agonistic mode of action toward hERα, whereas furan and pyran prenylation led to an antagonistic mode of action. Five of these antagonistic compounds had an agonistic mode of action in the U2-OS based hERα CALUX bioassay, implying that these compounds can act as SERMs. The yeast bioassay also identified 8 ER subtype-selective compounds, with either an antagonistic mode of action or no response toward hERα and an agonistic mode of action toward hERβ. The ER subtype-selective compounds were characterized by 6a-hydroxy-pterocarpan or 6a,11a-pterocarpene backbone structure. It is suggested that either the extra D-ring or the increase in length to 12-13.5 Å of these compounds is responsible for an agonistic mode of action toward hERβ and, thereby, inducing ER subtype-selective behavior.

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