Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 498581
Title Effects of sodium and potassium supplementation on endothelial function and inflammation in untreated (pre)hypertensives: a fully controlled dietary intervention study
Author(s) Gijsbers, L.; Dower, J.I.; Schalkwijk, C.G.; Kusters, Y.H.A.M.; Bakker, S.J.; Hollman, P.C.H.; Geleijnse, J.M.
Source Journal of Hypertension 33 (2015)S1. - ISSN 0263-6352 - p. e72 - e72.
Event 25th European Meeting on Hypertension and Cardiovascular Protection, Milan, Italy, 2015-06-12/2015-06-15
Department(s) Human Nutrition (HNE)
Chair Nutrition and Disease
RIKILT - BU Toxicology Bioassays & Novel Foods
Publication type Abstract in scientific journal or proceedings
Publication year 2015
High sodium and low potassium have been associated with detrimental effects on blood pressure. However, the role of these minerals in endothelial dysfunction and low-grade inflammation, which may predispose to cardiovascular disease, has not yet been established. We performed a randomized placebo-controlled crossover study to examine the effects of sodium and potassium supplementation on endothelial function and inflammation in untreated (pre)hypertensive adults.

During the study, subjects were on a fully controlled diet that contained on average 2.4 g of sodium and 2.3 g of potassium per day for a 2500 kcal intake. After one-week run-in, subjects were randomized to ingest capsules with supplemental sodium (3 g/d), supplemental potassium (3 g/d), or placebo, for four weeks each, in random order. After each intervention period, brachial artery flow-mediated dilation, and circulating biomarkers of endothelial function (e.g. nitric oxide, endothelin-1, cellular adhesion molecules) and inflammation (e.g. tumor necrosis factor-α, C-reactive protein, interleukins) were measured.

Of 37 randomized subjects, 36 completed the study. Subjects had a mean pre-treatment blood pressure of 145/81 mmHg. Sodium supplementation increased serum endothelin-1 by 0.24 pg/ml (95% CI: 0.03, 0.45), but had no effect on other endothelial or inflammatory biomarkers, or flow-mediated dilation. Potassium supplementation reduced interleukin-8 levels by 0.28 pg/ml (95% CI: 0.03, 0.53), without affecting other circulating biomarkers. Flow-mediated dilation was 1.16% (95% CI: 0.37, 1.96) higher after potassium supplementation than after placebo, with 83% of the subjects showing an improvement (Figure).

Sodium and potassium supplementation had little impact on circulating endothelial and inflammatory biomarkers, and only for potassium an effect on flow-mediated dilation was observed. This study suggests different actions for sodium and potassium in the pathophysiological processes leading to cardiovascular disease.(Figure is included in full-text article.).
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