Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 499224
Title Apolipoprotein E genotype status affects habitual human blood mononuclear cell gene expression and its response to fish oil intervention
Author(s) Matualatupauw, J.C.; Radonjic, M.; Rest, O. van de; Groot, C.P.G.M. de; Geleijnse, J.M.; Müller, M.R.; Afman, L.A.
Source Molecular Nutrition & Food Research 60 (2016)7. - ISSN 1613-4125 - p. 1649 - 1660.
Department(s) Chair Nutrition Metabolism and Genomics
Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Disease
Human Nutrition (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2016
Abstract Scope
People who carry the apolipoprotein E4 (APOE4) single nucleotide polymorphism have an increased risk of cardiovascular disease (CVD). Fish-oil supplementation may help in the prevention of CVD, though interindividual differences in the response to n-3 PUFAs have been observed. We aimed to assess the impact of APOE genotype on peripheral blood mononuclear cell whole genome gene expression at baseline and following a fish-oil intervention.

Methods and results
Participants received 6 months of fish-oil supplementation containing 1800 mg of eicosapentaenoic acid and docosahexaenoic acid per day. APOE genotype and peripheral blood mononuclear cell whole genome gene expression before and after supplementation were measured. We characterized the differences in gene expression profiles in carriers of APOE4 (N = 8) compared to noncarriers (N = 15). At baseline, 1320 genes were differentially expressed and the fish-oil supplementation differentially regulated 866 genes between APOE4 carriers and noncarriers. Gene set enrichment analysis showed that carriers had a higher gene expression of cholesterol biosynthesis and IFN signaling pathways. Fish-oil supplementation reduced expression of IFN-related genes in carriers only.

The increased expression of IFN signaling and cholesterol biosynthesis pathways might explain part of the association between APOE4 and CVD. Fish-oil supplementation may particularly benefit APOE4 carriers by decreasing expression of IFN-related genes.
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