Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 499498
Title House dust mite-specific IgA2 is associated with protection against eczema in allergic patients
Author(s) Hartog, G. Den; Neerven, R.J.J. Van; Boot, J.D.; Jansen, A.P.H.; Savelkoul, H.F.J.
Source Allergy 71 (2016)4. - ISSN 0105-4538 - p. 563 - 566.
Department(s) Cell Biology and Immunology
De Haar Varkens / PluimveeDe Haar Varkens / Pluimvee
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) eczema - house dust mite allergy - IgA - saliva - serum

Upon inhalation, house dust mite (HDM) allergens are deposited at the nasal and oral mucosa, where IgA is produced abundantly. IgA subclasses have been linked to protection against respiratory allergy previously. It is currently not known whether and how the human IgA subclasses IgA1 and IgA2 contribute to the clinical status of house dust mite-allergic patients. Saliva and serum samples were collected, and HDM-specific, IgE, IgG4, IgA1 and IgA2 levels were determined. HDM-specific levels of IgA in serum were similar to levels measured in nonallergic controls, but HDM-specific levels of IgA2 in saliva were decreased in allergic subjects. HDM-allergic patients who suffered from rhinitis and eczema showed a significant decrease in IgA2-levels compared to patients who suffered from rhinitis only. Taken together, our findings indicate that HDM-specific IgA2, but not IgA1, levels in serum and saliva are reduced in HDM-allergic patients suffering from eczema.

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