Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 501705
Title Clickable Polylactic Acids by Fast Organocatalytic Ring-Opening Polymerization in Continuous Flow
Author(s) Berg, Sebastiaan A. van den; Zuilhof, Han; Wennekes, Tom
Source Macromolecules 49 (2016)6. - ISSN 0024-9297 - p. 2054 - 2062.
Department(s) Laboratory for Organic Chemistry
Publication type Refereed Article in a scientific journal
Publication year 2016

The use of microreactor technology for the ring-opening polymerization of l-lactide catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene allows for rapid optimization of reaction parameters (reaction temperature and residence time). At moderate catalyst loading, good control over the polymerization is demonstrated by high conversion of monomer (>95%) and low polydispersity (<1.3) at residence times as low as 2 s. This metal-free, organocatalytic route yields well-defined poly(lactic acid) in continuous flow and by using bicyclononyne- and tetrazine-containing initiators gives access to poly(lactic acid) amenable to click Chemistry.

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