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Record number 501719
Title Transport and metabolism of fumaric acid in Saccharomyces cerevisiae in aerobic glucose-limited chemostat culture
Author(s) Shah, Mihir V.; Mastrigt, Oscar van; Heijnen, Joseph J.; Gulik, Walter M. van
Source Yeast 33 (2016)4. - ISSN 0749-503X - p. 145 - 161.
DOI https://doi.org/10.1002/yea.3148
Department(s) Food Microbiology Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Fumaric acid - Futile cycling - Metabolism - Permeability coefficient - saccharomyces cerevisiae - Transport mechanism
Abstract

Currently, research is being focused on the industrial-scale production of fumaric acid and other relevant organic acids from renewable feedstocks via fermentation, preferably at low pH for better product recovery. However, at low pH a large fraction of the extracellular acid is present in the undissociated form, which is lipophilic and can diffuse into the cell. There have been no studies done on the impact of high extracellular concentrations of fumaric acid under aerobic conditions in S. cerevisiae, which is a relevant issue to study for industrial-scale production. In this work we studied the uptake and metabolism of fumaric acid in S. cerevisiae in glucose-limited chemostat cultures at a cultivation pH of 3.0 (pH

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