|Title||Use of Ambient Ionization High-Resolution Mass Spectrometry for the Kinetic Analysis of Organic Surface Reactions|
|Author(s)||Sen, Rickdeb; Escorihuela, Jorge; Smulders, Maarten M.J.; Zuilhof, Han|
|Source||Langmuir 32 (2016)14. - ISSN 0743-7463 - p. 3412 - 3419.|
Laboratory for Organic Chemistry
|Publication type||Refereed Article in a scientific journal|
In contrast to homogeneous systems, studying the kinetics of organic reactions on solid surfaces remains a difficult task due to the limited availability of appropriate analysis techniques that are general, high-throughput, and capable of offering quantitative, structural surface information. Here, we demonstrate how direct analysis in real time mass spectrometry (DART-MS) complies with above considerations and can be used for determining interfacial kinetic parameters. The presented approach is based on the use of a MS tag that - in principle - allows application to other reactions. To show the potential of DART-MS, we selected the widely applied strain-promoted alkyne-azide cycloaddition (SPAAC) as a model reaction to elucidate the effects of the nanoenvironment on the interfacial reaction rate.