Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 503677
Title The intestinal microenvironment and functional gastrointestinal disorders
Author(s) Barbara, Giovanni; Feinle-Bisset, Christine; Ghoshal, Uday C.; Santos, Javier; Vanner, Stepen J.; Vergnolle, Nathalie; Zoetendal, Erwin G.; Quigley, Eamonn M.
Source Gastroenterology 150 (2016)6. - ISSN 0016-5085 - p. 1305 - 1318.e8.
DOI http://dx.doi.org/10.1053/j.gastro.2016.02.028
Department(s) Microbiological Laboratory
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Bile Acids - Food - Functional Dyspepsia - Immune System - Irritable Bowel Syndrome - Microbiota - Serotonin
Abstract

For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in the role of various luminal factors and their interactions with each other and the host in functional gastrointestinal disorders. Most prominent among these factors has been the role of food. As a consequence, although not always evidence-based, dietary interventions are enjoying a renaissance in irritable bowel syndrome management. Not surprisingly, given its exploration in many disease states, the gut microbiota has also been studied in functional gastrointestinal disorders; data remain inconclusive. Likewise, there is also a considerable body of experimental and some clinical data to link the pathogenesis of functional gastrointestinal disorders to disturbances in epithelial barrier integrity, abnormal enteroendocrine signaling, and immune activation. These data provide growing evidence supporting the existence of micro-organic changes, particularly in subgroups of patients with functional dyspepsia and irritable bowel syndrome. However, their exact role in the complex pathophysiology and symptom generation of functional gastrointestinal disorders needs to be further studied and elucidated, particularly with longitudinal and interventional studies.

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