Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 504252
Title Enhancing the interpretation of statistical P values in toxicology studies: implementation of linear mixed models (LMMs) and standardized effect sizes (SESs)
Author(s) Schmidt, Kerstin; Schmidtke, Jörg; Kohl, Christian; Wilhelm, Ralf; Schiemann, Joachim; Voet, Hilko van der; Steinberg, Pablo
Source Archives of Toxicology 90 (2016)3. - ISSN 0340-5761 - p. 731 - 751.
Department(s) Biometris (PPO/PRI)
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) 90-day toxicity study - ANOVA - Linear mixed models - P values - Repeated measurements - Standardized effect sizes

In this paper, we compare the traditional ANOVA approach to analysing data from 90-day toxicity studies with a more modern LMM approach, and we investigate the use of standardized effect sizes. The LMM approach is used to analyse weight or feed consumption data. When compared to the week-by-week ANOVA with multiple test results per week, this approach results in only one statement on differences in weight development between groups. Standardized effect sizes are calculated for the endpoints: weight, relative organ weights, haematology and clinical biochemistry. The endpoints are standardized, allowing different endpoints of the same study to be compared and providing an overall picture of group differences at a glance. Furthermore, in terms of standardized effect sizes, statistical significance and biological relevance are displayed simultaneously in a graph.

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