Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 504686
Title A gain-of-function polymorphism controlling complex traits and fitness in nature
Author(s) Prasad, K.V.S.K.; Song, B.; Olson-Manning, C.; Anderson, J.T.; Lee, C.; Schranz, Eric; Windsor, A.J.; Clauss, M.J.; Manzaneda, A.J.; Naqvi, I.; Reichelt, M.; Gershenzon, J.; Rupasinghe, S.G.; Schuler, M.A.; Mitchell-Olds, T.
DOI http://dx.doi.org/10.5061/dryad.kc6m8
Department(s) Biosystematics
EPS
Publication type Dataset
Publication year 2012
Keyword(s) glucosinolate - herbivory - ecological genomics - Boechera stricta
Toponym Rocky Mountains
Abstract Identification of the causal genes that control complex trait variation remains challenging, limiting our appreciation of the evolutionary processes that influence polymorphisms in nature. We cloned a quantitative trait locus that controls plant defensive chemistry, damage by insect herbivores, survival, and reproduction in the natural environments where this polymorphism evolved. These ecological effects are driven by duplications in the BCMA (branched-chain methionine allocation) loci controlling this variation and by two selectively favored amino acid changes in the glucosinolate-biosynthetic cytochrome P450 proteins that they encode. These changes cause a gain of novel enzyme function, modulated by allelic differences in catalytic rate and gene copy number. Ecological interactions in diverse environments likely contribute to the widespread polymorphism of this biochemical function.
Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.