Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 504960
Title Distinct physiological, plasma amino acid, and liver transcriptome responses to purified dietary beef, chicken, fish, and pork proteins in young rats
Author(s) Song, Shangxin; Hooiveld, G.J.E.J.; Li, Mengjie; Zhao, Fan; Zhang, Wei; Xu, Xinglian; Müller, M.R.; Li, Chunbao; Zhou, Guanghong
Source Molecular Nutrition & Food Research 60 (2016)5. - ISSN 1613-4125 - p. 1199 - 1205.
DOI http://dx.doi.org/10.1002/mnfr.201500789
Department(s) Chair Nutrition Metabolism and Genomics
VLAG
Human Nutrition (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2016
Abstract Young rats received semi-synthetic diets for 1 wk that differed only
regarding protein source; casein (reference) was replaced by beef, chicken, fish, or pork proteins.
Compared to casein, all proteins, except pork, increased total plasma AA concentrations.
Pork protein reduced adipose tissue mass and liver triacylglycerol, which was accompanied
by increased plasma triacylglycerol concentrations. Plasma cholesterol was reduced by fish
protein. The number of differentially expressed genes ranged between 609 (pork) and 1258
(chicken); on average one-third of the changes were specific for each meat protein. Pathway
responses were most similar for beef and chicken, followed by pork and fish. Although the
extent varied, allmeat proteins inducedmRNAtranslation, antigen processing/presentation, intracellular
vesicular trafficking, and oxidoreductive-transformation pathways, and suppressed
signal-transduction (Notch, TGFB/SMAD, insulin) and mitochondrial biogenesis pathways.
Lipid- and AA-metabolic pathways were repressed, except by pork. AA-transport pathways were
induced by beef and fish only, and complement/coagulation-pathways were suppressed by
chicken and beef. Fish suppressed nuclear-transport and cofactor metabolism.
Conclusion: To conclude, short-term feeding of different meat proteins resulted in distinct
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