Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 505380
Title Continuous-flow alcohol protection and deprotection reactions catalyzed by silica-supported sulfonic acid
Author(s) Berg, Sebastiaan A. van den; Frijns, Raoul A.M.; Wennekes, Tom; Zuilhof, Han
Source Journal of Flow Chemistry 5 (2015)2. - ISSN 2062-249X - p. 95 - 100.
DOI https://doi.org/10.1556/1846.2015.00006
Department(s) Laboratory for Organic Chemistry
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) Alcohol protection and deprotection - Catalysis - Continuous flow - Packed bed - Silyl ether
Abstract

Alcohol protection and deprotection reactions, catalyzed by solid-supported sulfonic acid, have been investigated under continuous-flow conditions. Primary, secondary, benzylic and phenolic alcohols can be protected under these conditions by tetrahydropyranyl and several silyl ether moieties, generating synthetically useful amounts of material in short time. Furthermore, the described setup can be used to deprotect protected alcohols and be used in selective protection reactions. Because the solid-supported acid catalyst is continually reused in a packed-bed approach, workup is greatly simplified and in most cases only solvent removal is necessary, while reaching high turn-over numbers.

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