Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 505394
Title Continuous purification of galacto-oligosaccharide mixtures by using cascaded membrane filtration
Author(s) Patil, Nirmal V.; Schotel, Thom; Rodríguez Gómez, Carol V.; Aguirre Montesdeoca, Victor; Sewalt, Jos J.W.; Janssen, Anja E.M.; Boom, Remko M.
Source Journal of Chemical Technology and Biotechnology 91 (2016)5. - ISSN 0268-2575 - p. 1478 - 1484.
Department(s) Food Process Engineering
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Continuous purification - Downstream processing - Filtration - GOS - Membrane cascade - Spiral wound membrane

BACKGROUND: Membrane filtration has the potential for purification of oligosaccharide mixtures. However, single stage performance is limited by the relatively low yield and purity that can be achieved. This paper explores the potential of a three-stage pilot-scale spiral wound membrane filtration cascade for the removal of monosaccharides and disaccharides from a galacto-oligosaccharide mixture. RESULTS: Two three-stage cascaded configurations with GH membranes were tested, one ideal-like configuration (cascade 1) and one adapted configuration (cascade 2). Cascade 1 performed well with regard to oligosaccharide yield (e.g. yield 84%, purity 0.46), while cascade 2 performed better in terms of oligosaccharide purity (e.g. yield 62%, purity 0.58). This might be compared with conventional single stage concentration which resulted in an oligosaccharide yield of 56% with a purity of 0.53. In addition these cascade configurations were explored using different membranes (GE and GK membranes) in each stage. CONCLUSION: The yield and purity in the cascaded systems were higher than the yield and purity of a single stage system with volume reduction. The yield and purity can be further enhanced by using an inhomogeneous cascade with different membranes in each stage.

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