Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 505718
Title Microbes and asthma : Opportunities for intervention
Author(s) Smits, Hermelijn H.; Hiemstra, Pieter S.; Prazeres Da Costa, Clarissa; Ege, Markus; Edwards, Michael; Garn, Holger; Howarth, Peter H.; Jartti, Tuomas; Jong, Esther C. De; Maizels, Rick M.; Marsland, Ben J.; McSorley, Henry J.; Müller, Anne; Pfefferle, Petra I.; Savelkoul, Huub; Schwarze, Jürgen; Unger, Wendy W.J.; Mutius, Erika Von; Yazdanbakhsh, Maria; Taube, Christian
Source Journal of Allergy and Clinical Immunology 137 (2016)3. - ISSN 0091-6749 - p. 690 - 697.
DOI http://dx.doi.org/10.1016/j.jaci.2016.01.004
Department(s) Cell Biology and Immunology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) asthma - helminths - Hygiene hypothesis - immune regulation - microbes - microbiome - sensitization - viruses
Abstract

The worldwide incidence and prevalence of asthma continues to increase. Asthma is now understood as an umbrella term for different phenotypes or endotypes, which arise through different pathophysiologic pathways. Understanding the many factors contributing to development of the disease is important for the identification of novel therapeutic targets for the treatment of certain asthma phenotypes. The hygiene hypothesis has been formulated to explain the increasing prevalence of allergic disease, including asthma. This hypothesis postulates that decreased exposure at a young age to certain infectious agents as a result of improved hygiene, increased antibiotic use and vaccination, and changes in lifestyle and dietary habits is associated with changes in the immune system, which predispose subjects to allergy. Many microbes, during their coevolution with human subjects, developed mechanisms to manipulate the human immune system and to increase their chances of survival. Improving models of asthma, as well as choosing adequate end points in clinical trials, will lead to a more complete understanding of the underlying mechanisms, thus providing an opportunity to devise primary and secondary interventions at the same time as identifying new molecular targets for treatment. This article reports the discussion and conclusion of a workshop under the auspices of the Netherlands Lung Foundation to extend our understanding of how modulation of the immune system by bacterial, parasitic, and viral infections might affect the development of asthma and to map out future lines of investigation.

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