Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 506056
Title Pneumococcal colonization and invasive disease studied in a porcine model
Author(s) Greeff, Astrid de; Selm, Saskia van; Buys, Herma; Harders-Westerveen, José F.; Tunjungputri, Rahajeng N.; Mast, Quirijn de; Ven, Andre J. van der; Stockhofe-Zurwieden, Norbert; Jonge, Marien I. de; Smith, Hilde E.
Source BMC Microbiology 16 (2016)1. - ISSN 1471-2180
DOI http://dx.doi.org/10.1186/s12866-016-0718-3
Department(s) CVI Infection Biology
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Animal model - Colonization - Pigs - Streptococcus pneumoniae
Abstract

Background: Streptococcus pneumoniae, a Gram-positive bacterium carried in the human nasopharynx, is an important human pathogen causing mild diseases such as otitis media and sinusitis as well as severe diseases including pneumonia, meningitis and sepsis. There is a strong resemblance between the anatomy, immunology and physiology of the pig and human species. Furthermore, there are striking similarities between S. suis pathogenesis in piglets and S. pneumoniae pathogenesis in humans. Therefore, we investigated the use of piglets as a model for pneumococcal colonization and invasive disease. Results: Intravenous inoculation of piglets with an invasive pneumococcal isolate led to bacteraemia during 5 days, showing clear bacterial replication in the first two days. Bacteraemia was frequently associated with fever and septic arthritis. Moreover, intranasal inoculation of piglets with a nasopharyngeal isolate led to colonization for at least six consecutive days. Conclusions: This demonstrates that central aspects of human pneumococcal infections can be modelled in piglets enabling the use of this model for studies on colonization and transmission but also on development of vaccines and host-directed therapies. Moreover this is the first example of an animal model inducing high levels of pneumococcal septic arthritis.

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