Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Record number 506074
Title Chemical composition and anti-inflammatory activity of the leaves of Byrsonima verbascifolia
Author(s) Saldanha, Aline Aparecida; Carmo, Lucas Fernandes Do; Nascimento, Sara Batista Do; Matos, Natália Alves de; Carvalho Veloso, Clarice de; Castro, Ana Hortência Fonsêca; Vos, Ric C.H. de; Klein, André; Siqueira, João Máximo de; Carollo, Carlos Alexandre; Nascimento, Thalita Vieira Do; Toffoli-Kadri, Mônica Cristina; Soares, Adriana Cristina
Source Journal of Natural Medicines 70 (2016)4. - ISSN 1340-3443 - p. 760 - 768.
DOI http://dx.doi.org/10.1007/s11418-016-1011-3
Department(s) PRI BIOS Applied Metabolic Systems
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Anti-inflammation - Byrsonima verbascifolia leaves - Flavonoids - Mass spectrometry - Nitric oxide
Abstract

An ethnopharmacological survey indicates that the genus Byrsonima has some medicinal species that are commonly found in the Brazilian Cerrado and has been used as an anti-inflammatory and for gastroduodenal disorders. The aim of this study was to evaluate the anti-inflammatory and antioxidant activity along with qualitative chemical characterization of the methanolic extract of the leaves of Byrsonima verbascifolia (BvME) obtained by exhaustive percolation. The data from the chemical analyses by liquid chromatography–mass spectrometry led to tentative identification of 42 compounds belonging to proanthocyanidins, galloyl quinic acid derivatives, flavonoids, and triterpene glycoside derivatives. BvME contain flavonoids and show an antioxidative activity. The methanolic extract administered intraperitoneally at doses of 50, 100, or 300 mg/kg showed a significant reduction in paw edema and modulated the neutrophil influx in a mouse model. Furthermore, the anti-edematogenic activity of the extract provided in smaller doses (12.5 and 25 mg/kg) was also demonstrated in a mouse paw edema model. The extract inhibited NO production by macrophages induced by lipopolysaccharide. We presume that the anti-inflammatory effects of BvME are due to a combination of compounds present in B. verbascifolia, including catechins (procyanidins), flavonoids, and triterpene glycosides and that these anti-inflammatory actions should be mediated, at least partly, through the inhibition of NO production. This study supports and validates the ethnopharmacological uses of B. verbascifolia as an anti-inflammatory.

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