Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 506645
Title Pseudoxylallemycins A-F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802 : A Competitor of Fungus-Growing Termite Cultivars
Author(s) Guo, Huijuan; Kreuzenbeck, Nina B.; Otani, Saria; Garcia-Altares, Maria; Dahse, Hans Martin; Weigel, Christiane; Aanen, Duur K.; Hertweck, Christian; Poulsen, Michael; Beemelmanns, Christine
Source Organic Letters 18 (2016)14. - ISSN 1523-7060 - p. 3338 - 3341.
Department(s) Laboratory of Genetics
Publication type Refereed Article in a scientific journal
Publication year 2016

Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.

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