|Title||Pseudoxylallemycins A-F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802 : A Competitor of Fungus-Growing Termite Cultivars|
|Author(s)||Guo, Huijuan; Kreuzenbeck, Nina B.; Otani, Saria; Garcia-Altares, Maria; Dahse, Hans Martin; Weigel, Christiane; Aanen, Duur K.; Hertweck, Christian; Poulsen, Michael; Beemelmanns, Christine|
|Source||Organic Letters 18 (2016)14. - ISSN 1523-7060 - p. 3338 - 3341.|
Laboratory of Genetics
|Publication type||Refereed Article in a scientific journal|
Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.