Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 506693
Title How to manipulate the microbiota : Fecal microbiota transplantation
Author(s) Fuentes Enriquez de Salamanca, Susana; Vos, Willem M. de
Source In: Microbiota of the Human Body / Schwiertz, Andreas, Springer (Advances in Experimental Medicine and Biology ) - ISBN 9783319312460 - p. 143 - 153.
Department(s) Microbiological Laboratory
Publication type Peer reviewed book chapter
Publication year 2016
Keyword(s) Clostridium difficile - Donor - Gastrointestinal microbiota - IBD - Microbial ecology - Regulation - Safety

Fecal microbiota transplantation (FMT) is a rather straightforward therapy that manipulates the human gastrointestinal (GI) microbiota, by which a healthy donor microbiota is transferred into an existing but disturbed microbial ecosystem. This is a natural process that occurs already at birth; infants are rapidly colonized by a specific microbial community, the composition of which strongly depends on the mode of delivery and which therefore most likely originates from the mother (Palmer et al. 2007; Tannock et al. 1990). Since this early life microbial community already contains most, if not all, of the predominantly anaerobic microbes that are only found in the GI tract, it is reasonable to assume that early life colonization is the ultimate natural fecal transplantation.

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