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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Record number 506736
Title Genetic parameters of cryptorchidism and testis size in Friesian colts
Author(s) Schurink, Anouk; Jong, Adrianne de; Nooij, Hans R. de; Hellinga, Ids; Ducro, Bart J.
Source Livestock Science 190 (2016). - ISSN 1871-1413 - p. 136 - 140.
DOI http://dx.doi.org/10.1016/j.livsci.2016.06.012
Department(s) Animal Breeding and Genetics
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Cryptorchidism - Friesian horses - Genetic parameters - Prevalence - Testis size
Abstract

In males with cryptorchidism, one or both testes do not descend into the scrotum thereby affecting among other things fertility. Testis size has been suggested to contribute to cryptorchidism. Therefore, the aim of our study was to estimate genetic parameters of cryptorchidism and testis size in Friesian colts. Data on cryptorchidism (0/1, n=1327) and testis size (cm, n=868 with size of both testes estimated) in Friesian colts of 1–7 months-of-age were gathered by a veterinarian during inspections from 2009 to 2012. Heritabilities, phenotypic and genetic correlations were estimated using ASReml4 including age of the colt (in months), location, year and month of inspection as fixed effects. Prevalence of cryptorchidism was 14.2%. Most affected colts (88.3%) were unilateral, while 11.7% were bilateral cases. Of the unilateral cases, significantly fewer colts had a left retained testis (35.5%) compared to a right retained testis (64.5%). Heritability of cryptorchidism was 0.13 (SE=0.06) and increased slightly when only cases of 4 months and older were considered. Based on literature and our findings we advise not to inspect colts at a very young age. Mean testis size significantly differed between left (3.47 cm) and right testis (3.19 cm). Heritability of left testis size (0.12±0.07) was lower compared to heritability of right testis size (0.31±0.10), where genetic correlation between left and right testis size was 0.87 (SE=0.12). The genetic correlation between left testis size and cryptorchidism was −0.94 (SE=0.15) and between right testis size and cryptorchidism was −0.64 (SE=0.23). At the age of the investigated Friesian colts, cryptorchidism genetically coincides with smaller testis size. The development of the left and right testis might differ, which could be hereditary in nature. More precise phenotyping, like recording position and size (and side) of the retained testis and age of the stallion, might contribute additionally to disentangling the genetic background of equine cryptorchidism and identifying the gene(s) affecting this disorder. For now, the continuation of the data recording as described in our study will enable the studbook to estimate breeding values and thereby select against cryptorchidism.

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