Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 507049
Title Approaches to sample size determination for multivariate data : Applications to PCA and PLS-DA of omics data
Author(s) Saccenti, Edoardo; Timmerman, Marieke E.
Source Journal of Proteome Research 15 (2016)8. - ISSN 1535-3893 - p. 2379 - 2393.
Department(s) Systems and Synthetic Biology
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) covariance estimation - dimensionality - eigenvalue distribution - hypothesis testing - loading estimation - multivariate analysis - power analysis - random matrix theory

Sample size determination is a fundamental step in the design of experiments. Methods for sample size determination are abundant for univariate analysis methods, but scarce in the multivariate case. Omics data are multivariate in nature and are commonly investigated using multivariate statistical methods, such as principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA). No simple approaches to sample size determination exist for PCA and PLS-DA. In this paper we will introduce important concepts and offer strategies for (minimally) required sample size estimation when planning experiments to be analyzed using PCA and/or PLS-DA.

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