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Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 507454
Title The importance of engineering physiological functionality into microbes
Author(s) Zhang, Yanping; Zhu, Yan; Yang Zhu, ; Li, Yin
Source Trends in Biotechnology 27 (2009)12. - ISSN 0167-7799 - p. 664 - 672.
Department(s) Bioprocess Engineering
Publication type Refereed Article in a scientific journal
Publication year 2009
Abstract Good physiological performance of industrial microbes is crucial for successful bioprocesses. Conventional metabolism-oriented engineering strategies often fail
to obtain expected phenotypes owing to focusing narrowly on targeted metabolic capabilities while neglecting microbial physiological responses to environmental stresses. To meet the new challenges posed by the
biotechnological production of fuels, chemicals and materials, microbes should exert strong physiological robustness and fitness, in addition to strong metabolic
capabilities, to enable them to work efficiently in actual bioprocesses. Here, we address the importance of engineering physiological functionalities into microbes and illustrate the operation procedure. We believe that this
physiology-oriented engineering strategy is a promising approach for improving the physiological performance of industrial microbes for efficient bioprocesses.
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