|Title||Modeling competition between yeast strains|
|Author(s)||Gee, Maarten de; Mourik, Hilda Van; Visser, Arjan De; Molenaar, Jaap|
|Source||In: AIP Conference Proceedings, Bandung, Indonesia, 4–6 November 2015. - American Institute of Physics - ISBN 9780735413702|
|Event||Symposium on Biomathematics, SYMOMATH 2015, Bandung, 2015-11-04/2015-11-06|
Biometris (WU MAT)
Laboratory of Genetics
|Publication type||Contribution in proceedings|
We investigate toxin interference competition between S. cerevisiae colonies grown on a solid medium. In vivo experiments show that the outcome of this competition depends strongly on nutrient availability and cell densities. Here we present a new model for S. cerevisiae colonies, calculating the local height and composition of the colonies. The model simulates yeast colonies that show a good fit to experimental data. Simulations of colonies that start out with a homogeneous mixture of toxin producing and toxin sensitive cells can display remarkable pattern formation, depending on the initial ratio of the strains. Simulations in which the toxin producing and toxin sensitive species start at nearby positions clearly show that toxin production is advantageous.