Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 507949
Title Entropy-Based Network Representation of the Individual Metabolic Phenotype
Author(s) Saccenti, Edoardo; Menichetti, Giulia; Ghini, Veronica; Remondini, Daniel; Tenori, Leonardo; Luchinat, Claudio
Source Journal of Proteome Research 15 (2016)9. - ISSN 1535-3893 - p. 3298 - 3307.
DOI https://doi.org/10.1021/acs.jproteome.6b00454
Department(s) Systems and Synthetic Biology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) metabolite modules - metabolite-metabolite association networks - metabolomics - network multiplex
Abstract

We approach here the problem of defining and estimating the nature of the metabolite-metabolite association network underlying the human individual metabolic phenotype in healthy subjects. We retrieved significant associations using an entropy-based approach and a multiplex network formalism. We defined a significantly over-represented network formed by biologically interpretable metabolite modules. The entropy of the individual metabolic phenotype is also introduced and discussed.

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