Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 508097
Title Cortical phase changes measured using 7-T MRI in subjects with subjective cognitive impairment, and their association with cognitive function
Author(s) Rooden, Sanneke van; Buijs, Mathijs; Vliet, Marjolein E. van; Versluis, Maarten J.; Webb, Andrew G.; Oleksik, Ania M.; Wiel, Lotte van de; Middelkoop, Huub A.M.; Blauw, Gerard Jan; Weverling-Rynsburger, Annelies W.E.; Goos, Jeroen D.C.; Flier, Wiesje M. van der; Koene, Ted; Scheltens, Philip; Barkhof, Frederik; Nieuwerth-van de Rest, Ondine; Slagboom, P.E.; Buchem, Mark A. van; Grond, Jeroen van der
Source NMR in Biomedicine 29 (2016)9. - ISSN 0952-3480 - p. 1289 - 1294.
Department(s) Chair Nutrition and Health over the Lifecourse
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) AD pathology - Alzheimer's disease - brain imaging - cognition - human 7-T MRI - phase - subjective cognitive impairment

Studies have suggested that, in subjects with subjective cognitive impairment (SCI), Alzheimer's disease (AD)-like changes may occur in the brain. Recently, an in vivo study has indicated the potential of ultra-high-field MRI to visualize amyloid-beta (Aβ)-associated changes in the cortex in patients with AD, manifested by a phase shift on T2*-weighted MRI scans. The main aim of this study was to investigate whether cortical phase shifts on T2*-weighted images at 7 T in subjects with SCI can be detected, possibly implicating the deposition of Aβ plaques and associated iron. Cognitive tests and T2*-weighted scans using a 7-T MRI system were performed in 28 patients with AD, 18 subjects with SCI and 27 healthy controls (HCs). Cortical phase shifts were measured. Univariate general linear modeling and linear regression analysis were used to assess the association between diagnosis and cortical phase shift, and between cortical phase shift and the different neuropsychological tests, adjusted for age and gender. The phase shift (mean, 1.19; range, 1.00–1.35) of the entire cortex in AD was higher than in both SCI (mean, 0.85; range, 0.73–0.99; p <0.001) and HC (mean, 0.94; range, 0.79–1.10; p <0.001). No AD-like changes, e.g. increased cortical phase shifts, were found in subjects with SCI compared with HCs. In SCI, a significant association was found between memory function (Wechsler Memory Scale, WMS) and cortical phase shift (β = –0.544, p = 0.007). The major finding of this study is that, in subjects with SCI, an increased cortical phase shift measured at high field is associated with a poorer memory performance, although, as a group, subjects with SCI do not show an increased phase shift compared with HCs. This increased cortical phase shift related to memory performance may contribute to the understanding of SCI as it is still unclear whether SCI is a sign of pre-clinical AD.

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