Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 508822
Title Predictive utility of a genetic risk score of common variants associated with type 2 diabetes in a black South African population
Author(s) Chikowore, T.; Zyl, Tertia van; Feskens, E.J.M.; Conradie, K.R.
Source Diabetes Research and Clinical Practice 122 (2016). - ISSN 0168-8227 - p. 1 - 8.
Department(s) Human Nutrition (HNE)
Chair Nutrition and Health over the Lifecourse
Publication type Refereed Article in a scientific journal
Publication year 2016
Abstract Aims To determine the predictive utility of polygenic risk scores of common variants associated with type 2 diabetes derived from the European and Asian ethnicities among a black South African population. Method Our study was a case-control study nested within the Prospective Urban and Rural Epidemiological (PURE) study of 178 male and female cases, matched for age and gender with 178 controls. Four types of genetic risk scores (GRS) were developed from 66 selected SNPs. These comprised of beta cell related variants (GRSb), variants which had significant associations with T2D in our study (GRSn), variants from the trans-ethnic meta-analysis (GRStrans) and all the 66 selected SNPs (GRSt). Results Of the GRS’s, only GRSn was associated with increased risk of T2D as indicated by an OR (95CI) of 1.21 (1.02–1.43) p-value = 0.015. Stratified analysis of age and BMI, indicated the GRSn to be significantly associated with T2D among the non-obese and participants less than 50 years. The area under the ROC of the T2D risk factors only was 0.652 (p value < 0.001) and with the addition of GRSn it was 0.665 (p value < 0.001). Conclusions The GRS of European and Asian derived variants have limited clinical utility in the black South African population. The inclusion of population specific variants in the GRS is pivotal.
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