|Title||Getting a grip on glycans : A current overview of the metabolic oligosaccharide engineering toolbox|
|Author(s)||Sminia, Tjerk J.; Zuilhof, Han; Wennekes, Tom|
|Source||Carbohydrate Research : an international journal 435 (2016). - ISSN 0008-6215 - p. 121 - 141.|
Laboratory for Organic Chemistry
|Publication type||Refereed Article in a scientific journal|
|Keyword(s)||Bio-orthogonal reactions - Chemical probes - Glycans - Glycobiology - Metabolic oligosaccharide engineering|
This review discusses the advances in metabolic oligosaccharide engineering (MOE) from 2010 to 2016 with a focus on the structure, preparation, and reactivity of its chemical probes. A brief historical overview of MOE is followed by a comprehensive overview of the chemical probes currently available in the MOE molecular toolbox and the bioconjugation techniques they enable. The final part of the review focusses on the synthesis of a selection of probes and finishes with an outlook on recent and potential upcoming advances in the field of MOE.