Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 509481
Title No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial
Author(s) Valk, J.P.M. van der; Gerth van Wijk, R.; Flokstra-de Blok, B.M.J.; Velde, J.L. van der; Groot, H. de; Wichers, H.J.; Dubois, A.E.J.; Jong, N.W. de
Source Pediatric Allergy and Immunology 27 (2016)8. - ISSN 0905-6157 - p. 812 - 817.
DOI http://dx.doi.org/10.1111/pai.12621
Department(s) Alterra - Earth informatics
FBR Consumer Science & Health
VLAG
CS Corporate Education, Research & InnovationCorporate Education, Research & Innovation
Food Quality and Design
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Anaphylaxis - Cashew nut allergy - Double-blind placebo-controlled food challenge - Food Allergy Quality of Life Questionnaire
Abstract

Background: Previous studies showed that health-related quality of life (HRQL) significantly improved after the food challenge, with greater improvements in HRQL after a negative outcome than after a positive outcome. It is currently unknown whether this also occurs in patients undergoing DBPCFCs with cashew nut in the context of a clinical trial. Methods: Quality of life was studied in children enrolled in a cashew nut study using Food Allergy Quality of Life Questionnaires (FAQLQs). Children, teenagers and parents of the children completed the questionnaires before the challenge test and 6 months after the DBPCFC with cashew nut. The difference in the change in HRQL between the children with a positive and negative DBPCFC outcome was studied by Mann-Whitney U-test. Results: In total, 112 children (67 boys, median age of 9 years) were included. The children, teenagers and parents of the children completed 143 sets of questionnaires in total. There were no significant differences in baseline total and domain scores compared to the follow-up scores in the FAQLQ-CF, FAQLQ-TF and FAQLQ-PF. In children, the delta FAIM score in the negative DBPCFC tested group was significantly better than the delta FAIM score in the positive challenged group (p = 0.026). There were no significant differences in the changes in the scores of the FAQLQ-CF and FAQLQ-PF in the children with a positive challenge outcome, compared to the children with a negative challenge result. However, there was a significant difference in the change in score between the latter groups in the domain 'accidental exposure' of the FAQLQ-TF (p = 0.049). Conclusion: This study showed no difference in the change in HRQL scores after a DBPCFC with cashew nut in children participating in a clinical trial. The utility of HRQL as an outcome for clinical trials in food allergy may be limited if participant baseline HRQL is relatively unimpaired.

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