|Title||Supramolecular Virus-Like Nanorods by Coassembly of a Triblock Polypeptide and Reversible Coordination Polymers|
|Author(s)||Hernandez-Garcia, Armando; Velders, Aldrik H.; Cohen Stuart, Martien; Vries, Renko de; Lent, Jan van; Wang, Junyou|
|Source||Chemistry-A European Journal 23 (2017)2. - ISSN 0947-6539 - p. 239 - 243.|
Physical Chemistry and Soft Matter
Laboratory of Virology
|Publication type||Refereed Article in a scientific journal|
|Keyword(s)||Coordination polymers - Hybrid nanomaterials - Polypeptides - Protein engineering - Self-assembly|
We investigate a new case of a self-assembly-stimulated self-assembly in which a triblock polypeptide is combined with a anionic coordination polymer of a dipicolinic acid bis-ligand, and d- or f- block metal ions like ZnII or EuIII. The polypeptide not only has a silk-like domain that can fold and stack, but also a C-terminal cationic sequence by which it can interact with the supramolecular (coordination) polyanion. In the presence of all three ingredients (polypeptide, bis-ligand, and metal ions), we observe the initiation and slow growth of well-defined metal-containing nanorods of up to 150nm in length, proving that self-assembly of the polypeptide is triggered by the self-assembly of the coordination polyelectrolyte and vice versa. The particles, which have a striking resemblance to rod-like viruses, are stable up to 1.2m NaCl, and can be made fluorescent when lanthanides like EuIII are used, showing the potential to exploit functional properties and applications of virus-like supramolecular structures.