Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 510836
Title Supramolecular Virus-Like Nanorods by Coassembly of a Triblock Polypeptide and Reversible Coordination Polymers
Author(s) Hernandez-Garcia, Armando; Velders, Aldrik H.; Cohen Stuart, Martien; Vries, Renko de; Lent, Jan van; Wang, Junyou
Source Chemistry-A European Journal 23 (2017)2. - ISSN 0947-6539 - p. 239 - 243.
DOI http://dx.doi.org/10.1002/chem.201603968
Department(s) BioNanoTechnology
VLAG
Physical Chemistry and Soft Matter
Laboratory of Virology
EPS
Publication type Refereed Article in a scientific journal
Publication year 2017
Keyword(s) Coordination polymers - Hybrid nanomaterials - Polypeptides - Protein engineering - Self-assembly
Abstract

We investigate a new case of a self-assembly-stimulated self-assembly in which a triblock polypeptide is combined with a anionic coordination polymer of a dipicolinic acid bis-ligand, and d- or f- block metal ions like ZnII or EuIII. The polypeptide not only has a silk-like domain that can fold and stack, but also a C-terminal cationic sequence by which it can interact with the supramolecular (coordination) polyanion. In the presence of all three ingredients (polypeptide, bis-ligand, and metal ions), we observe the initiation and slow growth of well-defined metal-containing nanorods of up to 150nm in length, proving that self-assembly of the polypeptide is triggered by the self-assembly of the coordination polyelectrolyte and vice versa. The particles, which have a striking resemblance to rod-like viruses, are stable up to 1.2m NaCl, and can be made fluorescent when lanthanides like EuIII are used, showing the potential to exploit functional properties and applications of virus-like supramolecular structures.

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