Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 511112
Title Cross-Family Transcription Factor Interactions : An Additional Layer of Gene Regulation
Author(s) Bemer, Marian; Dijk, Aalt-Jan van; Immink, Richard G.H.; Angenent, Gerco C.
Source Trends in Plant Science 22 (2017)1. - ISSN 1360-1385 - p. 66 - 80.
Department(s) PRI BIOS Plant Development Systems
Laboratory of Molecular Biology
PRI BIOS Applied Bioinformatics
Biometris (WU MAT)
Publication type Refereed Article in a scientific journal
Publication year 2017
Keyword(s) DNA binding - Protein interactions - TF families - Transcription factor - Transcription regulation
Abstract Specific and dynamic gene expression strongly depends on transcription factor (TF) activity and most plant TFs function in a combinatorial fashion. They can bind to DNA and control the expression of the corresponding gene in an additive fashion or cooperate by physical interactions, forming larger protein complexes. The importance of protein-protein interactions between members of a particular plant TF family has long been recognised; however, a significant number of interfamily TF interactions has recently been reported. The biological implications and the molecular mechanisms involved in cross-family interactions have now started to be elucidated and the examples illustrate potential roles in the bridging of biological processes. Hence, cross-family TF interactions expand the molecular toolbox for plants with additional mechanisms to control and fine-tune robust gene expression patterns and to adapt to their continuously changing environment. Large-scale studies are revealing many cross-family transcription factor (TF) interactions, supporting the idea that they play important roles in plant gene regulatory networks.Novel . in vitro and . in vivo approaches in combination with next-generation sequencing methods accelerate studies on TF functioning.Increasing numbers of TFs that play important roles as hubs connecting different genetic networks are being discovered.
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