Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 519849
Title The two-speed genome of Verticillium dahliae mediates emergence of potent virulence factors
Author(s) Thomma, B.P.H.J.; Faino, L.; Li, J.; Shi-Kunne, X.; Depotter, J.R.L.; Kramer, H.M.; Berg-Velthuis, G.C.M. van den; Cook III, David; Rövenich, H.J.; Seidl, M.F.
Source In: Book of Abstracts 29th Fungal Genetics Conference Asilomar 17, Pacific Grove, CA, USA 14-19 March 2017. - - p. 4 - 4.
Event 29th Fungal Genetics Conference, Pacific Grove, CA, 2017-03-14/2017-03-19
Department(s) Laboratory of Phytopathology
EPS
Publication type Abstract in scientific journal or proceedings
Publication year 2017
Abstract Genomic plasticity enables adaptation to changing environments, which is especially relevant for pathogens that engage in “arms races” with their hosts. In many pathogens, virulence genes reside in highly variable, transposon-rich, physically distinct genomic compartments. However, understanding of the evolution of such compartments, and the role of transposons therein, remains limited. We show that transposons are the major driving force for adaptive genome evolution in the fungal plant pathogen Verticillium dahliae, and that highly variable lineage-specific (LS) regions evolved by genomic rearrangements that are mediated by erroneous double-strand repair, often utilizing transposons. Remarkably, LS regions are enriched in active transposons, which may contribute to local genome plasticity. Thus, we provide evidence for genome shaping by transposons, both in an active and passive manner, which impacts the evolution of V. dahliae virulence. Based on this knowledge, we are now able to identify crucial virulence factors of V. dahliae, which also allows investigating causal relationships between particular effectors and pathotypes.
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