Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 523330
Title Effects of digested onion extracts on intestinal gene expression using rat intestine slices
Author(s) Wit, N.J.W. de; Hulst, M.M.; Govers, C.C.F.M.; Meulen, J. van der; Hoef, A.M.A. van; Stoopen, G.M.; Hamers, A.R.M.; Hoekman, A.J.W.; Vos, C.H. de; Bovee, T.F.H.; Smits, M.A.; Mes, J.J.; Hendriksen, P.J.M.
Department(s) FBR Consumer Science & Health
LR - Animal Breeding & Genomics
CVI Virology
CS Corporate Education, Research & InnovationCorporate Education, Research & Innovation
RIKILT - BU Toxicology Bioassays & Novel Foods
PRI BIOS Applied Metabolic Systems
Host Microbe Interactomics
CVI Infection Biology
Publication type Dataset
Publication year 2016
Keyword(s) Rattus norvegicus - GSE84179 - PRJNA328225
Abstract Rat small intestine precision cut slices were exposed for 6 hours to in vitro digested yellow (YOd) and white onion extracts (WOd) that was followed by transcriptomics analysis. The digestion was performed to mimic the digestion that in vivo takes place in the stomach and small intestine. The transcriptomics response of the rat small intestine precision cut slices was compared to that of human Caco-2 cells and the pig in-situ small intestinal segment perfusion. The microarray data for the human Caco-2 cells (GSE83893) and the pig in-situ small intestinal segment perfusion (GSE83908) have been submitted separately from the current data on rat intestine. The goal was to obtain more insight into to which extent mode of actions depend on the experimental model. A main outcome was that each of the three models pointed to the same mode of action: induction of oxidative stress and particularly the Keap1-Nrf2 pathway.
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