Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 523965
Title Association between DNA methylation profiles in leukocytes and serum levels of persistent organic pollutants in Dutch men
Author(s) Dungen, Myrthe van den; Murk, Tinka; Kampman, Ellen; Steegenga, Wilma; Gils-Kok, Dieuwertje van
Department(s) Sub-department of Environmental Technology
Marine Animal Ecology
Chair Nutrition and Disease
Chair Nutrition Metabolism and Genomics
Publication type Dataset
Publication year 2017
Keyword(s) Homo sapiens - GSE79329 - PRJNA315514
Abstract Genome-wide DNA methylation profiling was performed in Dutch men consuming eel from relatively low- or high-polluted areas, resulting in a broad range of serum POP levels. The Illumina Infinium 450K Human DNA methylation Beadchip v1.0HD was used to measure DNA methylation in these men and associate this with serum levels of persistent organic pollutants (POPs). In total 48 POPs were measured, of which 30 POPs had levels above the detection limit in at least 60% of the participants. Furthermore, 11 different clinical parameters were measured as biomarkers for health. The leukocyte count was measured in each sample to adjust DNA methylation values. Furthermore, participants reported possible confounders in a questionnaire.
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