Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 524148
Title The impact of gut microbiota on gender-specific differences in immunity
Author(s) Fransen, Floris; Beek, Adriaan A. van; Borghuis, Theo; Meijer, Ben; Hugenholtz, Floor; Gaast-de Jongh, Christa van der; Savelkoul, Huub F.; Jonge, Marien I. de; Faas, Marijke M.; Boekschoten, Mark V.; Smidt, Hauke; Aidy, Sahar El; Vos, Paul de
Source Frontiers in Immunology 8 (2017). - ISSN 1664-3224 - 14 p.
DOI https://doi.org/10.3389/fimmu.2017.00754
Department(s) Cell Biology and Immunology
WIAS
Nutrition, Metabolism and Genomics
VLAG
Microbiology
WIMEK
Publication type Refereed Article in a scientific journal
Publication year 2017
Keyword(s) Gender - Germ-free mice - Gut microbiota - Immunity - Inflammation
Abstract

Males and females are known to have gender-specific differences in their immune system and gut microbiota composition. Whether these differences in gut microbiota composition are a cause or consequence of differences in the immune system is not known. To investigate this issue, gut microbiota from conventional males or females was transferred to germ-free (GF) animals of the same or opposing gender. We demonstrate that microbiota-independent gender differences in immunity are already present in GF mice. In particular, type I interferon signaling was enhanced in the intestine of GF females. Presumably, due to these immune differences bacterial groups, such as Alistipes, Rikenella, and Porphyromonadaceae, known to expand in the absence of innate immune defense mechanism were overrepresented in the male microbiota. The presence of these bacterial groups was associated with induction of weight loss, inflammation, and DNA damage upon transfer of the male microbiota to female GF recipients. In summary, our data suggest that microbiota-independent gender differences in the immune system select a gender-specific gut microbiota composition, which in turn further contributes to gender differences in the immune system.

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