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Record number 525211
Title TNFalpha and IL-6 induced anorexia: effects on serotonin turnover
Author(s) Dwarkasing, Jvalini; Witkamp, Renger; Boekschoten, Mark; Laak, M.C. ter; Flik, G.; Norren, Klaske van
Department(s) Chair Nutrition and Pharmacology (HNE)
VLAG
Chair Nutrition Metabolism and Genomics
Publication type Dataset
Publication year 2016
Keyword(s) GSE69151 - Mus musculus - PRJNA284645
Abstract Anorexia can occur as a serious complication of chronic disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin levels. The present study was undertaken to further explore the connections between peripheral inflammation, anorexia and hypothalamic serotonin metabolism and signaling pathways. We studied transcriptomic changes and serotonergic activity in the hypothalamus of mice after an intraperitoneal injection with TNFα, IL-6 or a combination of TNFα and IL-6.
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