Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 525211
Title TNFalpha and IL-6 induced anorexia: effects on serotonin turnover
Author(s) Dwarkasing, Jvalini; Witkamp, Renger; Boekschoten, Mark; Laak, M.C. ter; Flik, G.; Norren, Klaske van
Department(s) Chair Nutrition and Pharmacology (HNE)
VLAG
Chair Nutrition Metabolism and Genomics
Publication type Dataset
Publication year 2016
Keyword(s) GSE69151 - Mus musculus - PRJNA284645
Abstract Anorexia can occur as a serious complication of chronic disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin levels. The present study was undertaken to further explore the connections between peripheral inflammation, anorexia and hypothalamic serotonin metabolism and signaling pathways. We studied transcriptomic changes and serotonergic activity in the hypothalamus of mice after an intraperitoneal injection with TNFα, IL-6 or a combination of TNFα and IL-6.
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