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Record number 525802
Title Gene expression profiling in human precision-cut liver slices upon treatment with the FXR agonist obeticholic acid [mouse]
Author(s) IJssennagger, Noortje; Janssen, Aafke; Kersten, Sander; Mil, S.W.C. van
Department(s) Chair Nutrition Metabolism and Genomics
VLAG
Publication type Dataset
Publication year 2016
Keyword(s) Mus musculus - GSE76162 - PRJNA306504
Abstract Background: The bile acid-activated farnesoid X receptor (FXR) is a nuclear receptor regulating bile acid, glucose and cholesterol homeostasis. Obeticholic acid (OCA; also known as INT-747 or 6α-ethyl-chenodeoxycholic acid), a promising drug for the treatment of non-alcoholic steatohepatitis (NASH) and type 2 diabetes, activates FXR. Mouse studies demonstrated that FXR activation by OCA (INT-747) alters hepatic expression of many genes. However, no data are available on the effects of OCA in human liver. Here, we generated gene expression profiles in human precision-cut liver slices (hPCLS) after treatment with OCA.
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