Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 530338
Title The impact of genome editing on the introduction of monogenic traits in livestock
Author(s) Bastiaansen, J.W.M.; Bovenhuis, H.; Groenen, M.; Megens, H.J.W.C.; Mulder, H.A.
Source In: Book of Abstracts of the 68th Annual Meeting of the European Federation of Animal Science. - Wageningen : Wageningen Academic Publishers (Book of abstracts 23) - ISBN 9789086863129 - p. 428 - 428.
Event Wageningen : Wageningen Academic Publishers (Book of abstracts 23) - ISBN 9789086863129 EAAP 68th Annual Meeting of the Animal Science (EAAP), Tallinn, 2017-08-28/2017-09-01
Department(s) WIAS
Animal Breeding and Genetics
Publication type Abstract in scientific journal or proceedings
Publication year 2017
Abstract The introduction of genome editing technologies provides new tools for the genetic improvement of animals and has the potential to become the next big game changer in animal breeding. The aim of our study was to investigate to
what extent genome editing in combination with genomic selection could accelerate the introduction of a monogenic trait as compared to a situation with genomic selection alone. A breeding population under genomic selection for
a polygenic trait was simulated. After establishing Bulmer equilibrium different selection scenarios, aiming to increase the polygenic trait and the allele frequency of the monogenic trait with or without genome editing, were compared for time to fixation of the desired allele, selection response in the polygenic trait, and level of inbreeding. In addition, the costs in terms of number of genome editing procedures were compared to the benefits of a higher cumulative proportion of the population with the desired phenotype for the monogenic trait and a lower genetic lag for the polygenic trait. Finally, the impact of efficiency of the editing procedure and survival rate of edited embryos were evaluated. Genome editing resulted in up to fourfold faster fixation of the desired allele, and the loss in long term selection response for the polygenic trait was up to threefold smaller than with genomic selection alone. In a population of 20,000 offspring per generation, the total number embryos edited to achieve fixation ranged from 22,610 with no selection to 7,080 with moderate selection and to 3,830 with high selection emphasis on the monogenic trait. With moderate selection emphasis on the monogenic trait, the total number of animals showing the undesired phenotype before fixation of the desired allele was reduced up to fourfold by adding genome editing. Genome editing had hardly any effect on inbreeding. A low editing efficiency (4%) had a major impact by increasing the number of editing procedures (+65%) and increasing the loss in selection response (+254%). Genome editing in commercial livestock breeding needs careful assessment of technical costs and benefits as well as ethical and welfare considerations.
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