Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 530676
Title Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
Author(s) Timmers, Silvie; Konings, Ellen; Bilet, Lena; Houtkooper, Riekelt H.; Weijer, Tineke van de; Hoeks, Joris; Krieken, Sophie van der; Ryu, Dongryeol; Kersten, Sander; Moonen-Kornips, Esther; Goossens, Gijs H.; Hesselink, Matthijs K.; Kunz, Iris; Schrauwen-Hinderling, Vera B.; Blaak, Ellen E.; Auwerx, Johan; Schrauwen, Patrick
Department(s) Chair Nutrition Metabolism and Genomics
Publication type Dataset
Publication year 2011
Keyword(s) Homo sapiens - GSE32357 - PRJNA14724
Abstract Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-blind cross-over study for 30 days. Resveratrol supplementation significantly reduced sleeping- and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1alpha protein levels, increased citrate synthase activity, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels, and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces profound metabolic changes in obese subjects, mimicking the effects of calorie restriction.
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